IV Ketamine Therapy

• • Treatments • •

IV Ketamine Therapy in Southern California

At Neuro Wellness Spa, we are proud to be one of the leading providers of intravenous (IV) ketamine therapy in Southern California. Although ketamine has been used safely as an FDA-approved anesthetic since the 1960s, the discovery of ketamine as a highly effective and rapid-acting treatment for a wide range of mood disorders and neuropathic pain has been hailed as arguably the most significant development in psychiatry during the past few decades.

Ketamine is a dissociative anesthetic that can help relieve symptoms of  depression, anxiety, PTSD, chronic pain and other disorders. Neuro Wellness Spa’s medical director, Dr. Martha Koo, MD, is an active member of the American Society of Ketamine Physicians. A leading authority on psychiatric disorders for over 20 years, Dr. Koo is passionate about using IV ketamine to help her patients.

What is Ketamine IV Therapy?

Millions of people struggle with treatment refractory psychiatric disorders, including anxiety, depression and PTSD. However, many of these conditions may stop responding to medications, like anti-depressants, and other therapies. IV ketamine therapy is a safe and effective treatment option for people who have not experienced satisfactory symptom relief from medications and talk therapy:

  • Depression
  • Anxiety
  • Acute suicidality
  • PTSD
  • Chronic pain

IV Ketamine Therapy works differently than commonly used antidepressants which may explain why people who aren’t helped by standard treatments respond to ketamine.

Ketamine has been used in hospitals for the past five decades and has a proven record of safety. The dose used to treat psychiatric patients is much smaller than what is used in hospitals. Ketamine for mood disorders is an outpatient procedure requiring no hospital admission.

Researchers at Mass General Hospital conducted the largest study of IV ketamine therapy. They found that over 70% of patients suffering from treatment-resistant depression experienced symptom relief with IV Ketamine Therapy. This study, along with a growing number of others, is a major finding that demonstrates the effectiveness of IV ketamine for those who have tried standard treatments but haven’t responded adequately.

What Can IV Ketamine Therapy Treat?

Depression is highly prevalent in the United States, and about 10-30% of patients who suffer from major depression do not respond to standard treatment methods.

If you have a treatment-refractory mental health condition, or have experienced unwanted side effects from standard treatment medications, you are not alone. IV ketamine therapy could be an effective treatment alternative.

IV Ketamine Therapy is a safe and effective treatment option for people who suffer from mood and chronic pain disorders. Ketamine has the ability to go to work rapidly, unlike most antidepressants which can take weeks to exert their full effects. Ketamine has been shown to help relieve symptoms of disorders including:

Bipolar Disorder

Bipolar disorder causes alternating feelings of depression and elation. IV ketamine therapy can help balance cerebral activity, and may alleviate some of the symptoms of bipolar disorder.

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Ketamine is effective in treating various chronic pain syndromes, especially those that have a neuropathic component, like fibromyalgia.

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Anxiety disorder is highly prevalent in the United States. According to the Anxiety and Depression Association of America, it affects about 40 million Americans, which is approximately 20% of the population. Ketamine therapy plays an important role in the treatment of anxiety. Approximately 30-40% of those seeking treatment for anxiety, do not achieve remission with standard medications and therapies. IV ketamine has been proven to effectively treat anxiety in patients with treatment-resistance.

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Chronic Pain

Ketamine is a powerful pain reliever. It has been used as an anesthetic during surgery. Ketamine is safe, especially compared to other anesthetics, because it offers fast-acting pain relief without causing respiratory suppression. There is growing evidence that treatment of chronic pain with ketamine provides prolonged pain relief.

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Spinal Injury

Ketamine can relieve pain caused by spinal cord injuries. Ketamine works by stimulating brain derived neurotrophic factor (BDNF) and the growth of neurons in the brain. Researchers have also observed increased synaptic connections in patients treated with IV ketamine therapy. This neuronal growth and increased neuronal interconnectivity relieve symptoms of spinal injuries.

Post Traumatic Stress Disorder

More than 3 million US adults suffer from PTSD each year. It is highly prevalent among military personnel, victims of domestic violence, and those who have suffered an accident or another type of traumatic event. IV ketamine has been shown to relieve symptoms of PTSD.

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The National Institute of Mental Health lists depression as one of the most common mental illnesses in the United States. In a recent study, around 17 million adults in the US had at least one major depressive episode in the past year.

However, standard antidepressant and therapy treatments do not work for everyone with depression. IV ketamine therapy is a well-established, safe and effective treatment option for those with treatment-resistant depression.

Phantom Limb Pain

Although there is still a lot unknown about phantom limb pain, it is clear that PLP involves both central and peripheral neural factors that activate N-methyl-D-aspartate (NMDA) receptors. Ketamine is known to block these NMDA receptors. Because of this, IV ketamine is considered to be a potentially effective treatment for many neuropathic disorders, including PLP.

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Neuralgia is a mild to severe, shooting pain felt along a nerve pathway. Although are different types of neuralgia, they all can affect the ability to perform everyday tasks and can reduce quality of life. If medications and nonpharmacological interventions don’t work, IV ketamine therapy may be a treatment option for neuralgia. IV ketamine is known for its ability to help relieve therapy-resistant chronic pain syndromes, especially those syndromes that have a neuropathic component, including neuralgia.

How Does IV Ketamine Therapy Work?

Ketamine works in several ways at the same time, many of which are still being studied.

Research has shown that ketamine stimulates brain derived neurotrophic factor (BDNF) and the growth of neurons in the brain. In patients treated with IV ketamine therapy, researchers have observed increased synaptic connections. Ketamine is known to stimulate the growth of neurons in as little as one hour. .

In 2016, the Society for Neuroscience published a major breakthrough explaining how ketamine causes new nerve cells to mature extremely quickly in the hippocampus. Dr. John Krystal, MD, the chief psychiatrist at Yale Medicine, even called this drug a “game changer”.

Ketamine also improves neural activation, or communication between brain cells by working as an NMDA receptor antagonist. This neuronal growth and increased neuronal interconnectivity have been shown to improve mood and cognition.

Medications like Valium, for example, only provide anti-anxiety effects for as long as the drug is in the system. Once Valium wears off, the symptoms of anxiety will typically return. With ketamine, on the other hand, the drug triggers a biological reaction in the cortex that allows the brain’s connections to regrow. Therefore, it’s the brain’s reaction to the drug that provides relief, rather than the drug itself.

Ketamine also may also work in other ways. For example, it might reduce signals involved in inflammation, which has been linked to mood disorders.

What to Expect from IV Ketamine Treatment

At Neuro Wellness Spa, our expert medical team administers IV ketamine treatments in a controlled environment using clinically established methods.


If you are interested in learning more about IV ketamine, our medical team will schedule you for a consultation. One of our psychiatrists will review your medical records, discuss your needs and preferences, and together you can decide whether IV ketamine therapy may be an effective treatment for you.

Your initial evaluation session provides an opportunity for you to build rapport with the psychiatrist and provide them with some background about yourself and the reasons you are seeking IV Ketamine Therapy. In addition to seeing if you will be a good candidate for Ketamine Infusion Therapy, they will be able to answer your questions regarding services, confidentiality, and what to expect in treatment. With your best interests in mind, you will decide together what kind of treatment will benefit you the most.


At your second appointment, you will work with a therapist to set goals for your overall mental health experience and then begin working together towards achieving them. In this session, you will establish intentions that will shape your IV Ketamine Therapy experiences and integration work. The stronger and clearer the intention, the more profound it may help the therapy to be.

IV Ketamine Therapy

When used to treat mood disorders, ketamine is administered through an IV at a much lower dose than is necessary for anesthesia. The dose of ketamine used in your treatment depends on your body weight: 0.5mg ketamine/kg body weight.

Each ketamine infusion lasts about 40 minutes, after which patients should have someone available to accompany them home safely. During the infusion, patients recline in a treatment chair surrounded by a calm, quiet and experientially safe environment. Ketamine is delivered at a slow and controlled dose and a registered nurse accompanies each patient for the duration of the infusion to monitor blood pressure, pulse and oxygen saturation. Patients do not experience any respiratory effects during or after the treatment.

IV Ketamine Therapy is well-tolerated. During a ketamine infusion, patients remain aware of their surroundings and experience a deep relaxation. Your clinician may lower the lights, offer an eye mask or aromatherapy, or take other measures to make the setting more comfortable.

Some patients may experience dissociation, perceptual disturbances or nausea. Generally, any changes in perception or dissociation dissipate very quickly after the infusion. However, many patients report that feelings of dissociation experienced during the infusion can help them develop an objective perspective about past experiences.

Typically, patients receive 8-12 ketamine infusions over the course of 3-4 weeks. The combination, frequency, and order of each of your treatment sessions will be discussed with you and will be recommended based on your unique circumstances.

Most patients experience positive results from ketamine after their first infusion. Subsequent infusions help prolong the positive effects.


In each integration session, a therapist will work with you to derive meaning from what occurred during your IV Ketamine Therapy experience, and translate that awareness into tangible everyday life practices. Integration work takes the IV Ketamine Therapy experience and turns it into sustainable, impactful change.

*Coming Soon!

Is IV Ketamine Therapy Covered by Insurance?

Although IV ketamine is FDA-approved as an anesthetic, it is used off-label to treat mood and chronic pain disorders. At the present time, ketamine infusions for mood and chronic pain disorders are cash pay procedures.

We recognize that there are financial considerations to take into account when starting treatment. Our team is always available to discuss and answer any questions you may have about your payment options.

Contact Neuro Wellness Spa

Your first step is to call us to schedule your no-cost consultation.

At Neuro Wellness Spa, our patients are our number one priority; we take their health and well being very seriously and are pleased to be able to offer IV Ketamine Therapy.

If you’ve tried other treatment options unsuccessfully, you are not alone. Many patients with treatment-refractory conditions have experienced symptom relief with IV Ketamine Therapy.

To learn more about IV Ketamine Therapy, or one of the other wellness services we offer, contact our expert clinical team today.

We accept insurance from the following providers

• • Testimonials • •

You Are Not Alone

Here’s What Our Patients Are Saying

  • It’s Almost Indescribable

    star star star star star

    It felt like a weight or a fog had lifted. Every area of my life turned around. I feel better, my sleep and my relationships are better. It’s almost indescribable.

  • TMS Changed Everything

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    I was so low energy and TMS changed everything. Now, I look forward to starting my days. My focus has improved. I appreciate things I couldn’t even notice before

  • Wish I Had Been Aware of This Years Ago

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    After about ten treatments, people started asking me what changed and why I seemed so much happier. It’s been over 3 months since my treatments ended and my symptoms have not returned.

  • I Feel Like I Have Come Alive Again

    star star star star star

    TMS allowed me to get over the initial hump to make the life changes necessary to live with and manage my depression.

  • My Brain Is In A Better Place

    star star star star star

    I’m two or three months past my last MeRT treatment, and I can honestly say my brain is in a better place than it was before. The emotional highs and lows I was living with have been stabilized. My cognition took off during that period and it hasn’t slowed down since.

    N.H., Retired NFL Player
  • He’s Been More Talkative and Engaged

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    After just two weeks of MeRT treatment, our son’s mood is brighter. He’s been more talkative and engaged with our family.

    MeRT Patient
  • The MeRT Technology Saved My Life

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    I went from dependence on opioids, SSRI’s, Benzes and sleep meds to clear in less than 6 weeks. The MeRT technology saved my life.

    J.S., SEAL Team 6
  • We Got Our Son Back

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    After eight weeks of MeRT treatments, he’s now much more verbal and much happier. He started communicating with us and making jokes. And he has a love of music we didn’t even know about. We got our son back.

    MeRT Patient
  • Ketamine Therapy Changed My Life

    star star star star star

    My life has completely changed. I experienced so much growth during the entire treatment process. I think I grew more in those six months than I had during my entire life. My therapist even said she had never seen such incredible progress with my PTSD in such a short amount of time.


For more information about the services we offer or whether TMS treatment is covered by your insurance provider, contact us today.

• • Get in touch • •

Contact Us

    Could TMS Therapy Be Right For You?

    I have been diagnosed with depression

    I am currently experiencing symptoms of depression (sadness, low energy, poor concentration, appetite changes, irritability)

    I have tried or am currently on antidepressant medications

    I have tried, or am currently on, 3 or more antidepressant medications

    I have tried talk therapy

    Has your doctor/therapist suggested you try TMS?

    Call Us Today

    Call Us Today